Description
5-Amino-1MQ (5-amino-1-methylquinolinium) is a small, membrane-permeable quinolinium compound designed as an inhibitor of nicotinamide N-methyltransferase (NNMT). NNMT methylates nicotinamide using S-adenosylmethionine, linking it to both the NAD+ salvage pathway and cellular methylation balance.
Preclinical research has examined 5-Amino-1MQ in cultured adipocytes, where NNMT inhibition was associated with changes in intracellular NAD+ and SAM levels and reduced lipogenesis, and in diet-induced obese mice, where its effects on adipose tissue and metabolic parameters were studied. More recent work has investigated NNMT inhibition in models of muscle stem-cell function in aged mice. Its selectivity over related methyltransferases has been examined in enzyme assays.
Keep sealed, cool and protected from light.
For laboratory research use only. This product is not a medicine, food or cosmetic and is not for human or veterinary use.
Supplied as a 10-vial kit of lyophilised powder. Dispatched in 1–2 business days.




